Harder for T cells to fight cancer in absence of VEGF-A

Contrary to what was previously believed, the immune system’s cancer-killing T cells are more effective in a tumor’s anoxic environment when they have access to growth factor VEGF-A. Researchers now show how the T cells not only survive in this oxygen-depleted micro-environment with the help of transcription factor HIF-1a but also become more effective at killing cancer cells inside it.

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