Rapamycin treatment prevents crippling abnormal bone formation after severe limb injuries

Individuals with severe injuries to their extremities often develop abnormal extra-skeletal bone in damaged or healing tissue, known as heterotopic ossification (HO). This post-traumatic abnormal wound healing can interfere with recovery, causing chronic pain, reduced mobility, and impaired prosthetic limb function. Rapamycin, an FDA-approved drug already on the market, was found to dramatically reduce the presence of HO in rats, suggesting it has potential to become the first effective treatment to prevent HO.

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