Scientists found a gene variant that affects cholesterol levels also could increase the risk of contracting typhoid fever. A common cholesterol-lowering drug could protect animal models against Salmonella Typhi, the culprit behind the potentially deadly infection. The findings give insight into the mechanisms that govern human susceptibility to infectious disease and point to possible avenues to protect against pathogens — like Salmonella or Ebola — whose entry into host cells is regulated by cholesterol.
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